Clinical Methods
Stephens & Associates has an extensive computerized library of protocols to help you evaluate and substantiate the safety and efficacy of your products. Examples of various clinical parameters/endpoints and their corresponding claim(s) (in parentheses) by product type are listed below.

Soap Bars, Cleansers and Detergents
Modified soap chamber (mild to skin)
Flex wash procedures (mild to skin)
Exaggerated arm wash procedures (mild to skin)
Forearm submersion (mild to skin)

Facial and Body Skin Care

Elasticity and firmness (makes skin firmer and more resilient)
Textural changes (improves skin texture; softens and smoothes skin)
Skin lightening or skin tone improvements (improves or evens skin tone)
Oil/sebum control (reduces the appearance of shine, improves makeup wearability; controls oil breakthrough)
Stratum corneum replacement time (rapidly exfoliates and reduces dead skin cells)
Wrinkles and fine lines (reduces the appearance of fine lines and wrinkles)
Facial pores (reduces the appearance of facial pores; will not clog pores)
Skin clarity assessments (skin appears clearer, brighter, more translucent, and radiant)
Body contouring products (reduces the appearance of stretch marks and cellulite)
Compatibility with topical prescription products (Retin A®, Renova®, etc. compatibility)

Moisturization
Kinetic or timed moisturization (moisturizes up to x hours better than a competitive brand)
Moisturization regression techniques (relieves the symptoms of dry skin)
Barrier enhancement/moisturization assessments (helps heal damaged skin)

Glamour Usage Studies
Foundations (covers blemishes, fines lines, and pores; moisturizes; long-wearing formula)
Lipsticks and liners (moisturizes; covers; does not bleed or feather; long wearing formula)
Foundations (non-comedogenic and non-acnegenic; will not clog pores)
Eye shadows, make-up removers, eye pencils, mascaras, eyeliners and other eye area products (smudge proof, long wearing formula, ophthalmologist tested; safe for sensitive eyes; safe for contact lens wearers)
 
Eye Area Safety
Human eye instillation/eye discomfort study (no tears; no stinging)
Controlled usage with special populations (ophthalmologist tested; safe for contact lens wearers; safe for sensitive eyes)
Sub-acute 5 day exaggerated use study (safe for consumers)

Specialized Claims for Skin Care
Pruritic (itchy) skin assessment (helps relieve the symptom of itchy skin)
Blood flow changes (helps bring nutrients to tissue)
Increased oxygen uptake (brings oxygen to tissue)
Facial sting test potential (non-sting formula)

Photobiology/SPF/Tanning/Sunless Tanners/Skin Lightening
Phototoxicity
Photoallergy
SPF screening or pilot test (5 person test)
SPF-FDA 1999 Monograph (USA procedure)
SPF-COLIPA (European procedure)
UVA protection using estimates of PFA (protection factor from
UVA exposure)
and PA (protection grade)
Sunburn cell and inflammatory cell test (to avoid warning/cautionary labels on AHA products)
Tanning studies (tan acceleration)
Sunless tanning studies (assessments of color intensity, evenness of color, speed in color development, and long-lasting coverage)
Skin lightening studies (improves uneven skin tone and the appearance of sun spots)

Safety Tests
Controlled usage tests with adults, adolescents or pediatric populations (safe for use; dermatologist tested)
4 hour patch test for irritation hazard classification (proposed DOT procedure)
24 hour and 48 hour patch tests for acute skin irritation (primary irritation)
7 day, 14 day and 21 day cumulative skin irritation tests
Soap chamber studies (mildness assessment)
Human Repeat Insult Patch Test (HRIPT) (Type IV allergy test)
Modified maximization test (Type IV allergy test)
Scalp irritation assessments (mildness assessment)
Deodorant (safety in a deodorant sensitive population)
Feminine hygiene (safety and efficacy)
Diaper and diaper rash studies (safety and efficacy; mildness assessment)