S&A has developed a unique five-pronged multidimensional approach that ensures the successful substantiation of product performance claims in clinical research. Subject Selection The success of a clinical trial is dependent on the appropriate screening and selection of subjects. Using its trained recruiters and a computerized database of subjects, S&A can rapidly select a subject population that will meet even the most rigorous protocol eligibility requirements.   Human Perception of Product Benefit The subject's perception of how a test product performs is a highly relevant dimension in product testing. Subjects' perceptions of product benefit can be captured through the use of study questionnaires, focus group interviews, and research guidance tests.   Clinical Assessment and Documentation Photography Our clinical graders include degreed technicians and Ph.D. and M.D. Investigators. Investigators are trained in grading methodology and ICH-GCP guidelines. Results of treatment changes as seen by the clinical graders can be further documented using state-of-the-art digital photographic techniques including Canfield and custom designed equipment.   Non-Invasive Bioengineering Methods An integral part of claim substantiation is the ability to support clinical assessment and the subject's perceptions of product benefit using objective biophysical instrumentation and methods. S&A has a full complement of bioinstrumentation to measure blood flow rates, skin dryness, skin hydration/moisturization, skin elasticity/firmness, fine line/wrinkle reduction, skin oxygen levels, skin thickness, facial oiliness, etc.   Statistically Based Conclusions Data analysis is as important as experimental design and execution in determining the success of a study. Analysis methods are chosen that extract the most information from the data and therefore provide the most general inferences. The choice of analytical method depends upon informational goals and fundamental data characteristics.